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To start with, we assessed benzodiazepine therapies initiated greater than 5 years (6 several years in the sensitivity analysis) prior to the analysis of Alzheimer’s disorder, a time period when prescriptions were more unlikely for being inspired from the prodromes on the condition.
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Last but not least, we are unable to rule out different hypotheses. By way of example, panic and slumber Problems, two of the principle indications for benzodiazepines, could be related to early β amyloid lesions in brain,42 fifty eight and persistent mid-life anxiousness can be connected with a increased chance of dementia in older persons.
A meta-analysis of these expression profiles was executed to derive novel conclusions and also to validate the recognised findings.[seventy two]
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